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Without sufficient NAD+, these enzymes cannot functionwhich explains why the decline in NAD+ with age leads to a cascade of cellular dysfunctions (Katsyuba et al., Nat Metab 2020)

The study enrolled 30 children with ASD (19 males and 11 females) diagnosed according to DMS-V and confirmed through ADOS/ADI-R, while excluding those with neurodevelopmental comorbidities, chronic medical conditions, gastrointestinal diseases, or special diets