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Preliminary clinical findings presented at the 2023 AAAS meeting (NCT04199728) reported a 40% reduction in opioid craving with liraglutide, although these results are pending peer-reviewed publication

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The reduced binding protein affinity also means more free IGF-1 LR3 remains available to interact with target tissues

The classes of antidiabetics currently in use are summarized in Table 1

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