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The Jianwei Shoutai Pill demonstrated an ability to attenuate ferroptosis both in vivo and in vitro through mechanisms that involve reducing iron accumulation, lipid peroxidation, and reactive oxygen species, while simultaneously enhancing antioxidant defenses via increased expression of GPX4 and SLC7A11

However, the study was relatively small (40 participants), and the liposomal delivery method is considerably more expensive than standard oral supplements

In conclusion, SAC exerts antioxidant and anti-ferroptotic effects by modulating the Keap1/Nrf2/GPX4 signaling axis

Clinically, magnetic resonance imaging (MRI) was used to detect the elevated iron levels in the hippocampus of AD patients [94], which led to further experimental exploration of the relationship between iron and AD centered on the hippocampus

doi: 10.1021/acs.jafc.2c06162