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The accessibility tradeoff becomes relevant only when cost barriers would otherwise prevent treatment entirely, and even then requires closer medical monitoring

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Patients who experience severe gastrointestinal adverse effects with standard doses can benefit from customized treatment approaches: Ultra-low starting doses for sensitive patients Slower titration schedules to improve tolerability Alternative administration forms like sublingual solutions (though these lack clinical validation) Allergen-free options for patients with sensitivities to inactive ingredients 3