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What this mechanism does NOT prove: upregulating BDNF in an injured brain is not the same as enhancing cognition in a healthy one

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Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]

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13 However, it is not widely appreciated that some diseases are also associated with subnormal test results, defined as values below the lower limit of normal on local laboratory reports (Table 1)