Khaykina, E
Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis
Contributes to the conversion of fat into energy for muscular functions
death of heart muscle tissue due to an interruption in its blood supply Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Oxidative stress - a situation in which the production of reactive oxygen species exceeds the ability of an organism to eliminate or neutralize them Placebo - a chemically inactive substance Primary prevention - taking measures to prevent the onset of disease Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Reactive oxygen species (ROS) - highly unstable oxygen-containing compounds that react easily with nearby cellular structures, potentially causing damage Authors and Reviewers Originally written in May 2015 by: Giana Angelo, Ph.D

46 Several preclinical and clinical studies on ischemia-induced brain injury, Alzheimers disease (AD), Parkinsons disease (PD), and other neurodegenerative disorders have established that GLP-1RAs can cross the BBB and exert a significant neuroprotective effect
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