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When NNMT consumes NAD+ faster than it can be replenished, even well-functioning mitochondria can't maintain oxidative phosphorylation at optimal rates

Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations (FELASA) recommendations, and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb

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El-Kharashi OA, Mohamed DI, Khairy E, Ezzat SF, Zaki WS