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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

Enhanced Energy Expenditure via NNMT Inhibition : In preclinical models, 5-Amino-1MQ increased whole-body metabolic rate by redirecting cellular resources away from fat storage and toward active ATP production

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