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Timing the transition Timing is very important when switching from tirzepatide to semaglutide
While Dihexa-specific desensitization kinetics havent been comprehensively characterized, research on HGF and c-Met receptor signaling in other contexts indicates receptor downregulation begins within 24-48 hours of sustained agonist exposure, with maximum internalization occurring around 72 hours
[11] [20] Patients should not adjust doses independently but may discuss timing strategies with their healthcare provider
The elephant in the room: Durability of results for GLP-1s Given well-documented concerns about weight regain after discontinuing GLP-1s, stakeholders are prioritizing solutions for long-term weight managementincluding by keeping patients on therapy for longer