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Both medications activate the GLP-1 receptor, creating redundant signaling and heightened side effect risk without proportional benefit
Fibre-rich complex carbohydrates release energy slowly, helping to avoid the spikes and dips that come with refined carbohydrates
For instance, in the STEP 2 trial, nausea rates rose from 5% at the initial 0.25 mg dose to 15% when patients reached the 2.4 mg dose of semaglutide
The peptide influences multiple interconnected systems
Patients with certain GLP1R variants may experience faster appetite suppression and benefit from smaller, more frequent meals before injection, while those with specific FTO genetic markers might tolerate slightly larger pre-injection meals without nausea escalation