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3 The risk factors for methotrexate AEs include higher doses (3.5 g/m 2 ), rapid infusions, preexisting kidney impairment, older age (aged 50 years), and the concurrent use of medications that are nephrotoxic or that impair methotrexate clearance (eg, proton pump inhibitors, aminoglycosides, nonsteroidal anti-inflammatory drugs, penicillin and penicillin derivatives, amphotericin, probenecid)

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ChemMedChem 2022 , 17, e202200152.

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Participants receiving different forms of glutathione in studies have experienced varying outcomes

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