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Less fluid in the gut means: Less lubrication Firmer stools Slower transit Dehydration also concentrates electrolytes like calcium, which can have constipating effects

Pharmacokinetic and pharmacodynamic study of amodiaquine and its two metabolites after a single oral dose in human volunteers

17 FaraoniP.GnerucciA.RanaldiF.OrsiniB.RomanoG.FusiF

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Gastrointestinal symptoms have also been reported, including heartburn, abdominal pain, belching, nausea, vomiting, flatulence, constipation, and diarrhea (106)

D.BaeI.et al (2008)