MOTS-c is mitochondria-derived, working at the cellular energy level rather than signaling GH or repairing tissue
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It preferentially activates the growth hormone releasing aspects of these receptors while having less effect on the appetite stimulating pathways
Uncontrolled activation of these pathways is frequently observed in various cancers, including colorectal, breast, prostate, and lung cancers, promotes metastasis while inhibiting apoptosis and contributes to tumor growth and resistance to therapies [5]
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