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Approximately 70 percent of GPX3 is secreted by the basolateral membrane of renal proximal convoluted tubule (PCT) cells and into plasma through the basilar artery (Zhao et al., 2019

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Given its numerous functions, low levels of thiamine can lead to reduced energy production due to impaired mitochondrial function, which damages neurons, and cells that have high energy demands, making them particularly vulnerable to potential damage or cell death (40)