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GLP-1 drugs can help with weight loss, but they arent without risks

The SUMMIT trial, involving 731 individuals with HFpEF and obesity followed for a median of 104 weeks, revealed a 38% decrease in the composite endpoint of cardiovascular mortality or heart-failure deterioration events (HR: 0.62, 95%CI: 0.41-0.95, P = 0.026), driven primarily by fewer worsening heart-failure events (8.0% vs

Researchers dont know exactly why theres a gap between womens and responses to GLP-1s, but a few theories are emerging: The same GLP-1 dose may be more potent for women

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List prices after approval may land in the $900 to $1,300 range prior to rebates or discounts

Archived from the original on 12 August 2025