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In contrast to initial reports placing GSH synthesis to both plastids and cytoplasm, the first enzyme of the pathway, -glutamylcysteine synthetase, is strictly localized in plastids, at least in Arabidopsis (Wachter et al., 2005)

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As with other calcium channel blockers, hemodynamic measurements of cardiac function at rest and during exercise (or pacing) in patients with normal ventricular function treated with amlodipine besylate have generally demonstrated a small increase in cardiac index without significant influence on dP/dt or on left ventricular end diastolic pressure or volume

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Primarily stored in the liver , it also ensures important detoxification functions (18)

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