GLP-1 receptors in the brain The brain contains abundant GLP-1 receptors in key regions including the hippocampus, cerebral cortex, hypothalamus, thalamus, and globus pallidum 26
In mouse studies, NNMT inhibition reduced white adipose tissue mass by approximately 35% without any change in food intake
Por su carcter no selectivo, adems de MC1R activa el receptor MC4R en el sistema nervioso central, que media la excitacin sexual, la funcin erctil y la supresin del apetito
Carter BZ, Mak PY, Tao W, Ostermann LB, Mak D, Ke B, Ordentlich P, McGeehan GM, Andreeff M
This new trial built on a previous one published in NEJM last fall (I previously reviewed here) for the same indication, but the only difference was the inclusion of people with diabetes
Chapel-Crespo CC, Diaz GA, Oishi K