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contact your healthcare provider if this occurs as dose adjustment of these agents may be necessary [1] [2] Fatigue or dizziness may occur, especially during initial treatment Increased heart rate a modest increase has been observed in clinical trials Other important adverse effects that require medical attention include: Acute pancreatitis presenting as severe, persistent abdominal pain radiating to the back, often accompanied by nausea and vomiting

Environment Lack of safe places to exercise (parks, sidewalks, gyms) Large portion sizes Limited access to affordable fresh produce Genetics Genes may predispose some people to obesity, though lifestyle factors usually play a key role

The most common adverse events were mostly mild to moderate gastrointestinal events, which occurred more commonly with tirzepatide vs placebo

doi: 10.1097/CRD.0000000000000513, 111

Effects of LA on initial fatty degeneration LA regulates hepatic lipid metabolism by activating the AMPK pathway

308 (2):C164-175 107