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Dietary fiber and prebiotics and the gastrointestinal microbiota

3.3 Environmental factors While diet and dietary additives such as pro-, pre and antibiotics play major roles in the formation of the gut microbiota, the water environment provides a complex and diverse living environment for aquatic animals with many important factors affecting the GM (Spanggaard et al., 2000)

Specifically, reduced IL-12 hampers Th1 cell differentiation and macrophage activation, reduced IL-2 compromises T-cell proliferation, and reduced IFN- impairs intracellular defense [19]

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