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(2021c)

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates

For the Mitostress test, oxygen consumption rate was measured first without any supplementation (basal respiration), then cells were treated subsequently with 1 M oligomycin A (ATP-dependent respiration), 0.75 M FCCP (spare respiratory capacity), and a mixture of 1 M rotenone and 1 M antimycin A (non-mitochondrial oxygen consumption)

Am J Physiol Heart Circ Physiol 2021;320:H549-62.ArticlePubMed 82

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Certificate of Analysis (CoA) available for every batch