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The synergistic effect of combining hepsin with clinically low doses of NAC appeared to be more effective than the standard clinical care of high-dose NAC for APAP overdose

If you think you may have AGS, talk to your healthcare provider and seek immediate emergency care if you are having a severe allergic reaction

A phase IIb RCT in overweight patients with T2DM showed the efficacy of cotadutide in reducing weight and serum transaminases in comparison with placebo (NCT03235050)

Studies show patients regain roughly 60% of the weight they lost within the first year , with research projecting a return to pre-treatment weight within about 1.5 to 2 years

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However, the SmPC does include warnings about more serious potential complications including pancreatitis, cholelithiasis/cholecystitis, and dehydration potentially leading to acute kidney injury