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The NADP + /NADPH ratio was calculated for each condition, and the graph was plotted using the GraphPad Prism V9 program

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A review of recent pharmacological advances in the management of diabetes-associated peripheral neuropathy

That happened in 2018

These extracts caused DNA nicks, apoptosis, and cell cycle arrest in a dose- and time-dependent manner by increasing the production of reactive oxygen species (ROS) and lowering mitochondrial potential [93] possibly by blocking the Protein Kinase C (PKC) [94]

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