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In many ways, that is one of the most important moments

doi: 10.1017/S1461145707008401

T., McConnell, A

Rheumatology (Oxford) (2016) 55(1):17384

The standard prescribing and monitoring framework was not designed with the oldest patients in mind

This is often particularly aimed at stabilizing the active conformation of the peptide, as cyclization imparts conformational constraint which reduces the entropic cost of binding, resulting in stronger, more selective target interactions (Zorzi et al., 2017