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Ozempic is approved by the Food and Drug Administration (FDA) for the following uses: to improve blood sugar management in adults who have type 2 diabetes, when used along with diet and exercise to reduce the risk of major cardiovascular events (those related to the heart and blood vessels, such as heart attack, stroke, and death) in adults who have type 2 diabetes and cardiovascular disease to reduce the risk of complications from chronic kidney disease in adults with type 2 diabetes The FDA has not approved Ozempic for weight loss or long-term weight management

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GLP-1 inhibits FoxO1, promoting -cell proliferation, and enhances PDX1 activity, thereby stimulating cellular proliferation

doi: 10.1016/j.diabet.2020.06.005 164 LeeYHKimSHKangJMHeoJHKimDJParkSHet al

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