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The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb) for the placebo group which was statistically significant

Hair related effects often take 3 to 6 months

According to the authors, the funders had no role in the study's design, data collection, analysis, interpretation, manuscript preparation, review, approval, or publication decisions

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Their use in this context represents off-label prescribing, which requires careful clinical justification and informed patient consent

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