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It serves as the primary intracellular reducing agent for reactive oxygen species (ROS), a cofactor for glutathione peroxidase (GPx), and a central mediator of hepatic detoxification via glutathione Stransferase (GST) and the glutamyl cycle

4 Limitations of Berberine Treatment Berberine has a variety of activities that may be involved in alleviating Alzheimers disease, including antioxidant, neuroprotective, and anti-inflammatory effects (Rabbani et al., 1987), it is generally considered to be non-genotoxic and cytotoxic in clinical (Liu et al., 2016

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Pediatr Res 73 , 6874 (2013)

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