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[6] In summary, aside from hypersensitivity, the use of pyridoxine should be guided by clinical necessity, and caution exercised in populations vulnerable to potential risks of excipients or overdose

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The consistency of safety findings across these independent trials enhances confidence in the conclusions

The alarmingly high prevalence of obesity necessitates the need for more effective anti-obesity medications

Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism team