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Figure 1 T2DM is the most common type of diabetes mellitus, and it is widely recognised that insulin resistance (IR) plays a key role in the development of T2DM and its organ-related complications, but the pathogenesis of cognitive dysfunction in diabetes mellitus is not yet fully understood (5)

Additionally, melatonin may activate AMPK/SERCA2a to inhibit Ca 2+ overload and thus decrease calcium-dependent xanthine oxidase and ROS levels, ultimately resulting in dephosphorylation at Ser616 inhibiting migration on the surface of mitochondria and ultimately inhibiting mitochondrial fission in LPS-induced human umbilical vein endothelial cell injury ( 3.3 Melatonin regulates mitochondrial oxidative stress through autophagy As a highly conserved mechanism, autophagy degrades misfolding proteins or damaged organelles, to fulfill the recycling of amino acids and lipids (Xu et al., 2023

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Common, mild effects: Temporary soreness or redness at the injection site