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"One of the potential side effects of these medications is to delay gastric emptying, which has a unique risk or potential for aspiration for patients undergoing anesthesia

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While no effect of water volume with dosing on SNAC pharmacokinetics was observed, interestingly, SNAC exposure increased when shortening the post-dose fasting period from 120 to 30 min in the dosing conditions trial (Supplementary Fig

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[1] These are exceedingly uncommon and possibly coincidental findings

These findings indicate that clinicians can now recognise semaglutide as a vascular protective medication, with benefits that extend beyond lowering weight or A1C, said Subodh Verma (University of Toronto, Toronto, Canada), senior author of the STRIDE trial