Retention of this unmodified histidine in retatrutide preserves potent glucagon receptor agonism, which is a defining structural distinction compared to tirzepatide, where this position is also histidine but the molecule lacks meaningful glucagon receptor activity due to other sequence differences
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Retatrutide purchased from MedChemExpress
Jason Brett, principal US medical head for Novo Nordisk, told CNN in an interview
7A and B, internal infusion of 10 mol/L U73122 or 60 mol/L D609 for 6 min did not change GABA currents of GCs (control), then addition of exendin-4 for 6 min still suppressed the GABA currents (73.28% 5.09% of control, P 0.05)
