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TAK1 phosphorylates and activates the IB kinase (IKK) complex and MAPK kinases (MKKs), which in turn stimulates nuclear factor kappa B (NF-B) and activator protein 1 (AP-1) transcriptional activity leading to inflammation and cell survival (Mihaly et al., 2014)

The accumulating evidence suggests that both NO and ROS play key roles in PCD

GLP-1 receptor agonists are typically considered long-term treatments

Biological effects of GIP The Gastric Inhibitory Polypeptide (GIP), isolated for the first time from porcine small intestine in 1971 [27], was named as GIP on the basis of its ability to inhibit gastric hydrochloric acid secretion [28]

It removes the free radical intermediates, thus preventing the cascade and further damage [20]