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MariTide Name: Maridebart cafraglutide (MariTide, formerly AMG 133) Manufacturer: Amgen Current stage: US phase III trial currently underway (MARITIME, NCT06858839) Takeaway: The dual agonist/antagonist action of MariTide could promise higher weight loss with fewer side effects, with dosing at less frequent intervals but more studies are needed

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requires screening and monitoring Tirzepatide (GLP-1/GIP medication) What it is: Prescription GLP-1/GIP medication Primary effect: Appetite regulation and satiety Evidence for weight loss: Strong What to know: FDA-approved options exist for chronic weight management

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