[9,32-34] The mechanism of action seems to be promoting cellular glucose uptake by activating an enzyme called adenosine monophosphate kinase (AMPK)
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tirzepatide shows larger magnitude effects in diabetes trials and early PCOS observations
People with diabetes, especially those with pre-existing diabetic retinopathy, should report any visual changes promptly, as rapid improvement in blood glucose control with semaglutide may temporarily worsen retinopathy
Al Batran R, Almutairi M, Ussher JR