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Rats were fed vitamin K1 or vitamin K2 (menaquinone-4) at levels of 0, 10, 50, or 500 mg/kg for 6 weeks

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Skipping scheduled dose increases or doubling up on injections because a previous dose felt ineffective represents the most common patient error leading to overdose-like symptoms

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The reconstituted solution should be clear to slightly opalescentany cloudiness, particulates, or color change indicates peptide aggregation or contamination, and the vial should be discarded