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Using a proper technique and the correct needle gauge can minimize discomfort, but it is generally considered a more invasive method.

The activation of the Nrf2 pathway triggers a massive endogenous production of Phase II detoxification enzymes, including Heme Oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)

Sep 2012;4(3):409-414

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In practical terms, the medication is designed to extend a normal physiologic pathway rather than replace it with an unrelated mechanism

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