Dysregulation of dopaminergic neurotransmission and hypofunction of NMDA receptor activity are regarded as the core mechanisms of schizophrenia.90 Under normal physiological conditions, glutathione enhances NMDA receptor-mediated glutamatergic neurotransmission
Although these CAR-T treatments possess huge potential for RA patients, they may also leading side effects (e.g., Cytokine Release Syndrome, Immune Effector Cell-Associated Neurotoxicity Syndrome, B-cell Aplasia and Hypogammaglobulinemia, Tumor Lysis Syndrome and off-taget)
Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking
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