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The biologic effects of IGFs signaling on cancer Once activated by the ligands, IGF-IR and InsR may initiate diverse signaling pathways to regulate cell proliferation, differentiation, survival, metabolism, migration, and stemness (Fig

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Community-reported (anecdotal): headache, brain fog or mental fatigue, irritability, anxiety, nausea or other GI upset, appetite and sleep changes, blood-pressure changes, and skin reactions with transdermal-DMSO use

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Focal Adhesion Kinase (FAK) Pathway: The activation of FAK under laboratory conditions suggests that the peptide assists in reorganising the cellular cytoskeleton, allowing cells to move more efficiently across the testing substrate