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However, despite advancements in in vitro fertilization and embryo transfer (IVF-ET) techniques, the challenges of retrieving a low number of oocytes and obtaining low-quality oocytes persist, presenting ongoing difficulties for the reproductive medicine community (Conforti et al., 2025)

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In such cases, high-dose folinic acid (Leucovorin) therapy is necessary for optimal brain function, particularly in autism, seizures, developmental delay, and movement disorders

Of 50 biochemical pathways and 450 polar and lipid metabolites examined, the developmental regulation of the purine network was most changed

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