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To induce deletion of Ctnnb1 , the nursing mothers of K14-rtTA::teto-Cre::Ctnnb1 fl/fl pups and WT littermates were given water containing 1 mg/ml doxycycline (Sigma) and chow containing 2 g/1000 g doxycycline (Research Diets Company) for periods specified in the figures

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Further, we considered the effects of their mutual interaction

The safety profile across these trials was generally clean