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For patients who have not responded well to semaglutide or tirzepatide, or who have specific reasons to prefer a daily liraglutide regimen, Saxenda remains a valid clinical option

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A patient with favorable genetic predisposition to growth hormone anabolism (based on growth hormone receptor polymorphisms and IGF-1 signaling variants) may be a better candidate for dual therapy than someone with polymorphisms associated with protein catabolism