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The principal limitation of our study was that it is based on modelled data, though as outlined above, our results show good alignment with clinical studies, and model-based PK/PD simulations are a common way to evaluate formulation doseeffect relationships for comparative analysis in the absence of head-to-head studies [24]
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Additionally, novel strategies are needed to prevent premature degradation and minimize cytotoxicity, especially in immunocompromised patients
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