Tsuji-Naito et al 27 demonstrated that DHLHZn (sodium zinc dihydrolipoyl histidinate, compound of Zn2+/dyhydrolipoic acid derivative complex, which was developed for cosmetic/medical use) serves as a potentially effective skin-lightening agent, an effectiveness that is based on the compounds covalent scavenging of DOPAquinone, resulting in depigmentation
It plays a crucial role in combating oxidative stress, detoxifying the body, and promoting overall skin health
iScience (2021) 24(12):103509
(Springer International Publishing AG, Cham, Switzerland), 128
Larger trials would provide more precise effect estimates and detect smaller differences between groups
A 2019 systematic review published in the National Library of Medicine identified improvements in skin brightness across several small trials while emphasising the need for larger controlled studies before definitive claims can be made