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At a high level, GLP-1 receptor agonists (and dual agonists like tirzepatide) help with blood sugar and weight by improving insulin response, lowering glucagon (a hormone that raises blood sugar), and reducing appetite

Xing L, Zheng H, Cao Y, Che S

Terreros G, Prez M, Muoz-LLancao P, DEspessailles A, Martnez EA, Dagnino-Subiabre A

Baseline renal and hepatic assessment before starting, regular lipase monitoring because of pancreatitis risk associated with tirzepatide, and standardised follow-up appointments

The FDA requires that weight loss drugs demonstrate a minimum of 5% weight loss compared to placebo over one year to gain approval

The goal is to inject into the muscle belly overlying a rib or in the thick paraspinal muscles adjacent to the spine, not directly into the unprotected intercostal space