glp-1 effect on cholesterol L- cell-specific Abca1 deficiency impairs glucose homeostasis through defective production in mice Cardiovascular Protective Properties of GLP-1

44 GIP and effects on bone metabolism In agreement with direct receptor effects on osteoblasts and osteoclasts, GIP exerts both an anabolic and anti-catabolic action in bone

Customers will work with WW clinicians to determine the best medication and weight loss plan for their goals and needs

These challenges contribute to many patients stopping GLP-1 therapy

Key points GLP-1 is a hormone that increases insulin release and prevents the release of too much glucagon, helping manage blood glucose levels in individuals with type 2 diabetes GLP-1 receptor agonists, such as liraglutide and semaglutide, effectively reduce blood glucose levels Semaglutide is more effective than liraglutide at reducing blood sugar levels Tirzepatide is a newer GLP-1 receptor agonist that also mimics the actions of another hormone called GIP, which can also reduce blood sugar levels A randomised controlled trial showed that tirzepatide led to more significant blood sugar reductions than semaglutide across three doses Tirzepatide may be more effective than semaglutide at higher doses, but this needs further investigation Liraglutide and semaglutide are available in the UK and the US, while tirzepatide is only available in the US but is likely to be approved in the UK soon

A network meta-analysis published in the Journal of the Endocrine Society found retatrutide achieved 23.77% weight reduction compared to 16.79% for tirzepatide when standardized across trials, with absolute weight loss of 16.34 kg versus 11.82 kg

& Gross, M