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Research has shown that GLP-1, along with other gut-brain peptides like ghrelin, leptin, and galanin, acts on the mesolimbic dopamine system of the brain and influences the activation of this system by alcohol and other addictive drugs

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Therefore, the anaplerotic flow between the glutamate-glutamine cycle and the citric acid cycle, mediated by the pyruvate carboxylase enzyme, has been proposed to have detoxification capacities.63 Comparing the susceptibility to morphologic and functional changes of the astroglial and microglial cells under hyperammonemic conditions, astrocytes are more susceptible.64 The capacity of ammonia to free proinflammatory substances on the part of the microglia has also been studied in that context

Body fat continued to decrease, while muscle mass was maintained

And in some cases, recently expired, properly stored medication probably retains most of its potency

The bottom line GLP-1s represent a new era of blood sugar management and weight loss benefits