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The investigators concluded that decreased hepatic GSH concentrations in patients with liver disease may represent a contributing factor of liver injury susceptibility and toxicity risk in these patients

doi: 10.1038/d41573-023-00148-z 126 OtteD-MChoukeifeMPatwariTMayerG

3.3 Disruption of mitochondrial dynamics and quality control 3.3.1 Imbalanced mitochondrial fission and fusion Mitochondria are dynamic organelles that maintain network homeostasis through continuous fission and fusion (Quintana-Cabrera and Scorrano, 2023)

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Whether this decline is a cause or consequence of aging and disease remains an active area of research

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