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Young people in their 20s have much higher levels than people in their 60s

For example, an ASCT2targeting ADC, MEDI7247, demonstrated manageable thrombocytopenia and neutropenia along with a 16.4% objective response rate in a firstinhuman Phase 1 trial of relapsed/refractory hematologic malignancies

10.1007/s00726-012-1420-x 100

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R., Kim, Y

Compared to the liver, we observed that the kidney has: (1) similar increased use of energy-related metabolites and production of urea cycle and ammonia-related intermediates, suggesting a shared catabolism in AKI, and (2) higher pools of energy metabolism intermediates in AKI