Reach out to your doctor or pharmacist if you cannot keep liquids down, if vomiting or diarrhea lasts more than a day or two, or if you notice you are barely urinating, feel very dizzy or confused, or have swelling that is new for you
Nausea, diarrhea, and decreased appetite occur most frequently but typically improve within the first few weeks
This approach backfires almost universally
In animal models, GLP-1 receptor agonists reduce cocaine, methamphetamine/amphetamine, and nicotine-related behaviors, including drug taking, motivation to use, and relapse-like seeking
Lin, et al., 'Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids', Diabetes Obes
Retatrutide at 48 weeks was still accelerating