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While this risk has not been confirmed in human epidemiological studies, patients with personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use orforglipron or any GLP-1 receptor agonist

A direct head-to-head trial (NCT06662383, 800 patients) is underway with results in December 2026

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Weitere Voraussetzung fr die Eigensynthese ist jedoch auch die Anwesenheit von zahlreichen Cofaktoren wie Vitamin C, Niacin, Vitamin B6 und dem Spurenelement Eisen [12]

Sainath TN, et al

Patients are encouraged to communicate openly with their healthcare providers about any discomfort they experience