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Demand soared after the FDA approved Wegovy and Zepbound for weight loss in 2021 and 2023, respectively

The best results happen when the medicine is used along with healthy eating and exercise, and people may gain weight back if they stop taking the medicine

A recent trial comparing tirzepatide to semaglutide showed a greater increase in weight loss after a year, with losses of 15.3% with tirzepatide compared with 8.3% for semaglutide

Do you need to stay on a GLP-1 medication long term

And until the medical establishment adopts better metrics, understanding exactly where you fall on the BMI scale is the first step toward accessing GLP-1 therapy

Am J Ophthalmol 2025;274:24-31.ArticlePubMed 100